Endocrine Abstracts

Children born with low birth weight (LBW, below 2500 g) exhibit slower development with deficit of height susceptibility to recurrent infections, especially of respiratory tract and, in adulthood, an increased risk of developing syndrome X. One possible explanation could be an enhanced elimination of cells by apoptosis.The aim of this study was evaluate of mechanism of lipid peroxidation and activity of caspase 3 in children with low birth weight.<p ...

Introduction: Hypopituitarism can be caused by a number of different etiologic factors including metastatic cancer. Metastasis to the pituitary gland is rare, accounting for only 1.8% of all metastases, and is often detected incidentally by symptoms associated with hormone dysfunction like hyponatremia. Breast and lung cancer are the primary neoplasms with well established properties of pituitary infiltration. Metastases from gastric cancer are unusual and constitute less than...

Graves’ disease (GD) is hyperthyroidism associated with organ-specific autoimmune 14 inflammation. GD occurs more frequently in adults than in children, however, pediatric patients are 15 a therapeutic challenge due to cycles of remissions and relapses requiring constant monitoring at 16 every stage of treatment administered. Dendritic cells (DCs) are considered a link between innate 17 and adaptive immunity. DCs as antigen-presenting cells (APCs) are involved in antigen ...

Introduction: Adrenal cancer is a rare, highly invasive malignant tumour with the incidence estimated for approximately 0,5-2,0 cases per milion people annually. Considering the fact that adrenal cancer is very sporadic not much data on its epidemiology is available.Aim of the study: The aim of the study was to present the single-center data on the epidemiology of the adrenal cancer.Material and methods: Patients with the diagnosis...

Introduction: BCC is a congenital epithelial neck cyst, which occurs due to failure of the second branchial cleft to obliterate during embryogenesis. Development of PTC inside the cyst is extremely rare.Case description: A 29-year-old female presented to the endocrinology clinic with a gradually increasing painless mass in the right lateral region of the neck, identified on ultrasound examination as an anechoic cyst of size 2×2×5 cm with a smoo...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant condition characterized by varying combinations of endocrine tumors and commonly accompanying hyperplasia within the parathyroid gland, anterior pituitary and gastrointestinal tract. Heterozygous germline mutation of the tumor suppressor gene MEN1 is the most common cause of the disease. Molecular genetic testing of menin gene, in which mutation is known to cause MEN1 syndrome, detects pathogenic...

FSH receptor (FSHR) expression has been shown in gonadal tumours, as well as in endothelial tumour vessel cells of various cancers. FSHR, due to its transmembrane localization could be a good candidate for receptor-mediated targeted cancer therapy. In recent years, a number of membrane disrupting lytic peptides have been used for receptor-based cancer therapy. In the present study, we characterised the specificity and cytotoxicity of a lytic peptide Phor21 conjugated to three ...

Progesterone (P4) treatment has been shown to have a clear modulating effect on murine Leydig tumor cell (mLTC-1) function, including downregulation of luteinizing hormone receptor. We hypothesized that P4 would stimulate, whereas an antiprogestine mifepristone (MF) block tumor progression in vivo in a transgenic (TG) murine Leydig cell tumor model (inhibin-α promoter-driven SV40 T-antigen (inhα/Tag)) and act similarly on cell proliferation in vitro...

Antiprogestine mifepristone (MF) has been shown to inhibit ovarian epithelial cancer (OEC) cell growth in vitro and in vivo. Recent clinical trials with MF for human OEC were unsuccessful, for unknown reasons. Progesterone (P4) is believed to have preventive measures towards breast, endometrial or hOEC cancers. Hereby we analyzed the effects of P4 and MF on ovarian granulosa cell tumorigenesis (GCT) in vitro and in vivo...

Expression of the follicle-stimulating hormone receptor (FSHR) has been shown in gonads, gonadal tumors, and in endothelial tumor vessel cells of various cancers. We investigated the specificity and cytotoxicity of a fusion lytic peptide Phor21, conjugated to different FSHβ-chain fragments to ablate FSHR expressing cancer cells in vitro and in vivo. Cytotoxicity of 12 different Phor21-FSHβ conjugates was tested in HEK-293 cells, stably transfected w...